Fig. 6
VRC26.01 sublineage members have diverse CDRH3s but share intronic mutations. a Intron-only ML tree for all VRC26 lineage members. The Arg97 + disulfide clade is highlighted by number of shared intronic mutations with ADS-4. Representative sequences are marked with UMB (Upper Major Bifurcating). b The exon-only ML tree for all VRC26 members is shown with the location of the highlighted sequences in a indicated. c CDRH3 and intron alignment for the representative sequences marked in a and b. Longitudinal time points of isolation are indicated. VRC26.01 intronic mutations are labeled and sequences are colored by the number of these mutations that they possess. UMB-A and UMB-B have a tyrosine position near position 100 h and have diverse CDRH3s from VRC26.01. d CDRH3 and intron alignment of sequences that diverge from VRC26.01 but share one intronic mutation. Longitudinal time points are shown and the CDRH3 site that contains convergent mutations is circled
