Fig. 6

NPFFR2 signalling regulates bone homoeostasis. a, e Femoral length of male and female WT and Npffr2^−/− mice. b–d, f–h Cancellous bone volume, trabecular thickness and trabecular number of the distal femur in male and female WT and Npffr2^−/− mice. i, j, k, l Cortical bone volume and cortical thickness of the distal femur in male and female WT and NPFFR2^−/− mice. m, n Representative photomicrographs of the distal femoral metaphysis of male and female WT and Npffr2^−/− mice. Male: WT n = 10, Npffr2^−/− n = 6. female: WT n = 10, Npffr2^−/− n = 11. BV/TV, bone volume over total volume. Data were from mice at 19–20 weeks of age. Data are mean ± SEM. One-way ANOVA was used to determine difference among groups. ^∗∗p < 0.05 vs. WT