Table 4 BLT mice protection with ultra-LA-DTG from high dose vaginal HIV-1 challenges
From: Ultra-long-acting removable drug delivery system for HIV treatment and prevention
Mouse | hCD45 (%) | hCD4 (%) | Treatment | Virus for 1st challenge | Virus for 2nd challenge | Infecting virus | Presence of viral DNA in tissues | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lymph nodes | Spleen | Liver | Lung | Bone marrow | Org. | |||||||
C1 | 49.6 | 85.9 | Vehicle | CH040 | None | CH040 | + | + | + | + | + | + |
C2 | 84.0 | 92.4 | Vehicle | CH040 | None | CH040 | + | + | + | + | + | + |
C3 | 74.0 | 86.9 | Vehicle | THRO | None | THRO | + | + | + | + | + | + |
C4 | 84.3 | 87.2 | Vehicle | THRO | None | THRO | + | + | + | + | + | + |
C5 | 94.3 | 82.0 | Vehicle | THRO | None | THRO | + | + | + | + | + | + |
T1 | 74.6 | 87.5 | LA-DTG | CH040 | CH040 | None | − | − | − | − | − | − |
T2 | 84.4 | 88.4 | LA-DTG | CH040 | CH040 | None | − | − | − | − | − | − |
T3 | 73.2 | 89.8 | LA-DTG | THRO | CH040 | None | − | − | − | − | − | − |
T4 | 80.2 | 91.9 | LA-DTG | THRO | CH040 | None | − | − | − | − | − | − |
T5 | 67.2 | 93.0 | LA-DTG | CH040 | CH040 | CH040 | + | + | + | + | + | + |
Mean | 76.6 | 88.5 | ||||||||||
SD | 21.0 | 12.2 | ||||||||||
