Fig. 1 | Nature Communications

Fig. 1

From: Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Fig. 1

Characterization of potentiation of NMDAR EPSCs by GNE-8324. a Effect of GNE-8324 on NMDAR EPSCs in inhibitory neurons (Int, gray) and excitatory neurons (Ext, black). Sample traces of NMDAR EPSCs in inhibitory neurons (Int, upper) and excitatory neurons (Ext, lower) before and after application of GNE-8324. Scale bars, 50 pA/100 ms. b Quantification of potentiation shown in a. N = 5 (Ext + Veh), 7 (Ext + GNE-8324), 12 (Int + GNE-8324), and 5 (Int + Veh). *P < 0.05, one-way ANOVA with Tukey's correction. c GNE-8324 potentiation in inhibitory neurons also occurred at 35 °C. Left: Sample traces showing potentiation by GNE-8324. Scale bars, 40 pA/100 ms. Right: Population data. Error bars represent SEM

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