Fig. 8 | Nature Communications

Fig. 8

From: SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Fig. 8

Model depicting the NOTCH1–SHQ1–MYC axis in promoting T-cell leukemogenesis. NOTCH1 directly activates SHQ1 transcription. The resulting accumulation of SHQ1 protein optimizes the assembly of H/ACA snoRNPs and snRNA pseudouridylation, potentiating MYC pre-mRNA splicing. In addition to NOTCH1 transcriptional regulation of MYC, NOTCH1 induces SHQ1 expression and enhances MYC RNA processing, ultimately maximizing MYC expression in T-ALL. See discussion for more details

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