Fig. 6
From: Haplosaurus computes protein haplotypes for use in precision drug design
Frequencies of the thirteen FPR1 protein haplotypes. The frequency for the thirteen FPR1 protein haplotypes sequenced by MedImmune and the frequency in the 1000 Genomes European population inferred by allele frequency and by the Haplosaurus method are compared. a The four haplotypes for which binding and inhibitory activity of Fpro0155 was confirmed experimentally are highlighted in green. The five non-synonymous SNPs (following the numbering used for UniProt P21462) are highlighted at the upper right according to their topological localisation: extracellular (ext) in orange, transmembrane (tm) in yellow and intracellular (int) in blue. Letters represent amino acid abbreviations. b correlates the haplotype frequency determined by sequencing with allele frequency inferred by Haplosaurus
