Fig. 4 | Nature Communications

Fig. 4

From: The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Fig. 4

Dicentric chromosomes and chromosome instability. Representation of the possible origins of dicentric chromosomes that arise from chromosome/telomere fusions or neocentromere formation in the presence of a functional original centromere. During anaphase onset, the dicentric chromosome that is attached by opposing mitotic spindle fibers is trapped, leading to anaphase and chromosome bridges and, consequently, DNA damage and chromosome instability. Centromere inactivation could restore faithful segregation by preventing incorrect spindle attachment

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