Table 1 List of human tumors with the reported chromosome breaks around the centromere region

From: The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Chromosome involved

Type of tumor

Technique(s) used

Reference

18, 8, 7

Breast cancer

FISH, aCGH

Alsop et al.18, Cooke et al.19, Bièche et al.26

1, 18

Melanoma

FISH

Alsop et al.18, Smedley et al.27

18

Colorectal

FISH

Alsop et al.18

18, 8

Pancreatic

FISH, aCGH

Alsop et al.18, Cooke et al.19

Several

Squamous cell carcinoma

FISH, SKY, aCGH

Hermsen et al.28

Several

Adenocarcinoma

FISH, SKY, aCGH

Hermsen et al.28

Several

Oral squamous cell carcinoma

FISH

Hermsen et al.29

Mostly 3, 5

Head and neck squamous cell carcinoma

FISH, fiber-FISH, aCGH, MLPA

Martinez et al.30, Martins et al. 31

1

Non-Hodgkin’s lymphoma

FISH

Baccon et al.32

1

Multiple myeloma

FISH

Baccon et al.32

1

Ovarian cancer

FISH

Thompson et al.33

10, 14, 7, 21

Cervical squamous cell carcinoma

FISH

Backsch et al.20

Mostly 17

Hematologic malignancies

FISH

Adeyinka et al.21

Several

Prostate cancer

G-banding, SKY

Balachandar et al.22

17

Male breast cancer

MLPA, FISH

Lacle et al.23

1, 8

Hepatocellular carcinoma

Whole genome sequencing, aCGH

Fernandez-Banet et al.24

1, 7

Acute myeloid leukemia

FISH

Ganly et al.25

  1. FISH fluorescence in situ hybridization, f-FISH fiber FISH, aCGH array-based comparative genomic hybridization, SKY spectral karyotyping, MLPA multiplex ligation-dependent probe amplification, G-banding Giemsa banding, WGS whole-genome sequencing