Fig. 5
In vivo synergistic anti-tumor effect. a Plasma platinum concentration versus time after injection of cPt and the MNPs (2 mg Pt per kg) (n = 4). Biodistributions of Pt at different time points after injection of b MNPs and c cPt (2 mg Pt per kg) (n = 4). H heart, Li liver, St stomach, Lu lung, K kidney, Br brain, Sp spleen, In intestine, Bl bladder, T tumor. d Tumor growth curves for the mice after different formulations (n = 9). e Weight of U87MG tumors from the mice received different formulations. f Kaplan–Meier plots of the mice bearing U87MG tumors after treatment with different formulations. The irradiation density was 0.3 W cm–2 at 671 nm, and the irradiation time was 10 min. g H&E, TUNEL, and Ki67 staining of tumor tissues collected from the mice administrated with various formulations. Scale bar is 100 μM. The data are expressed as means ± s.d., ***P < 0.001
