Fig. 1
From: Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
E. coli coinfection leads to NK cell-mediated impairment of the anti-LCMV CTL response. NK cell-depleted and non-depleted B6 (a–c) or TLR2/4-deficient mice (d, e) were infected with LCMV. One day later, they were coinfected with E. coli or received sterile LB medium as control (ctrl) and were analyzed at day 8 after LCMV infection. a, d gp33- and np396-tetramer+ (tet) CD8 T cells in percent of spleen cells. b Absolute numbers (#) of splenocytes. c, e Viral titers in spleen and liver. Data of individual mice (n = 7–9 (a–c), n = 3–9 (d, e)) from 1–3 independent experiments with 2–4 mice per group are shown; horizontal bars represent the mean values. Dashed lines indicate detection limits. *p < 0.05, **p < 0.01, ***p < 0.001; one-way ANOVA with Tukey-Kramer post-test (a, b), Mann–Whitney (d, e), or Kruskal–Wallis Test with Dunn’s post-test (c)
