Fig. 6
From: Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
Deficiency in NCR1 or NKG2D does not prevent LPS-induced negative T cell regulation. NKG2D-deficient (a–d, n = 5), NKp46 icre/icre (e–h, n = 9–10) and B6.CD45.1-NcrC14R mice (i–l, n = 8–11) were infected with LCMV. One day later, they received LPS or PBS (ctrl). Mice were analyzed at day 8 after LCMV infection. a, e, i gp33- and np396-tetramer+ (tet) CD8 T cells in percent of spleen cells. b, f, j Percent NK cells (CD3–NK1.1+) of spleen cells. c, g, k Absolute numbers (#) of spleen cells. d, h, l Viral titers in spleen and liver. Data of individual mice from 2 to 3 independent experiments with 2–6 mice per group are shown; horizontal bars represent the mean values. Dashed lines indicate detection limits. *p < 0.05, **p < 0.01, ***p < 0.001; Mann–Whitney test
