Fig. 3

Associations between genome-wide oncogenic features and the mutation status of common driver genes. Dot plot depicting the relationships between mutation status in TP53, PIK3CA, CDH1, and GATA3, and mutation signatures (APOBEC C > T, APOBEC C > G, aging, HRD, and signature 8), missense mutation burden, and copy number (CN) segments a across all IHC subtypes (n = 500) and b within HR +/HER2 − (n = 222). Only TCGA data, including samples lacking mutation signature estimates, was used for CN associations (all subtype n = 1,023; HR +/HER2 − n = 635). No samples were excluded based on race/ethnicity. Comparisons between mutation status and genomic features were performed with Mann–Whitney U and P-values were corrected for multiple testing (Benjamini–Hochberg method). Circle size is proportional to the magnitude of the − log10 BH P-value (i.e., lower BH P-values have larger circles). If mutation status associated with a significant increase or decrease of a genomic feature, the corresponding circle is colored red or blue, respectively. Non-significant (NS) comparisons are colored black