Fig. 1 | Nature Communications

Fig. 1

From: Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

Fig. 1

Rare putative damaging variants in SLC22A12. a Scheme of the transcript variant 1 (NM_144585.3) onto which positions of each putatively damaging variant included in the SLC22A12 gene-based tests were mapped. Marker color reflects the association p-value with serum urate from the single-variant primary meta-analysis; b higher CADD phred score was significantly associated with larger negative effects on serum urate among the rare variants (beta = −0.05 per unit of CADD score, SE = 0.01, p = 2.3e-7)

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