Fig. 4 | Nature Communications

Fig. 4

From: Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

Fig. 4

Putative damaging variants with MAF < 5% in SLC2A9 (hSLC2Ab). Of the 90 variants included in primary gene-based test, 87 were missense, and 3 were splice variants. Of the 87 missense variants, 77 were found in the hSLC2A9b. The ± signs indicate variants selected for mapping onto the SLC2A9 predicted structure. Beta between −1.5 and −1.0 (−); beta < −1.5 (−−); beta between 1.0 and 1.5 (+); beta >1.5 (++), Orange: predicted transmembrane domains. Amino acid position based on NP_001001290 (ENSP00000422209)

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