Table 1 GWAS studies of nevus count contributing to the present meta-analysis
From: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Study | Nevus assessment | SNP chip | Imputation | Individuals (families) | Age range (mean) | Location (center) |
|---|---|---|---|---|---|---|
ALSPAC39 | Self-count on limbs | 550k | 1000Gv.3 | 3309 | 14–17 (15.5) | UK (Bristol) |
Harvard8 | Self-count >3 mm on limbs | Affy+Illumina various | 1000Gv.3 | 32,975 | 35–75 (52) | US (Boston) |
Leeds40 | Whole-body count >2 mm | OmniExpressExome | HRC v.1 | 397 | 21–80 (57) | Yorkshire |
QIMR BTNS children3 | Whole-body count >0 mm | 610k, CoreExome | 1000Gv.3 | 3261 (1309) | 9–23 (12.6) | SE Queensland (Brisbane) |
QIMR BTNS parents9 | Self-rating 4-point scale | 610k+CoreExome | 1000Gv.3 | 2248 (1299) | 29–72 (44.1) | SE Queensland |
QIMR adult twins41 | Self-rating 4-point scale | 317k+370k+610k+CE | 1000Gv.3 | 1848 (1113) | 29-–79 (52.3) | Australia wide |
QIMR >50 twins42 | Self-count right arm >4 mm | 370k+610k+CE | 1000Gv.3 | 893 (596) | 50–92 (60.7) | Australia wide |
Raine43 | Nurse-count right arm | 660k | 1000Gv.3 | 808 | 22 | Western Australia (Perth) |
Rotterdam44 | Whole-body rating 4-pt scale | 550k, 610k | 1000Gv.3 | 3319 | 51–98 (67) | Rotterdam (NL) |
TEST45 | Whole-body count >0 mm | 610k+CE | 1000Gv.3 | 136 (71) | 5–18 (9.7) | Tasmania+Victoria |
Twins UK5 | Whole-body count >2 mm | 317k+610k+1M+1.2M | 1000Gv.3 | 3312 (1839) | 18–80 (47) | UK wide (London) |
Total nevus | 52,506 | |||||
Melanoma GWASMA10 | 12,874 cases; 23,203 controls | |||||
Nevus+melanoma | 88,583 (inc. controls) |
