Fig. 5
From: Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
In vivo anti-cancer efficacy of mitochondria-targeted RDT. a Tumor growth inhibition/regression curves in MC38 tumor-bearing mice treated with PBS, Hf-DBA, DBB-Ru, or Hf-DBB-Ru by intratumoral (i.t.) injection with (+) or without (−) X-ray irradiation or Hf-DBB-Ru by intravenous (i.v.) injection followed by X-ray irradiation. n = 6. b Excised tumor weights on day 22. n = 6. c Tumor growth inhibition/regression curves in CT26 tumor-bearing mice treated with PBS with (+) or without (−) X-ray irradiation or i.v. injected with Hf-DBB-Ru followed by X-ray irradiation. Black arrows refer to i.v. injection of different treatments and red arrows refer to X-ray irradiation. Excised tumor weights on day 21 shown in the inset. n = 6. **P < 0.05, ***P < 0.001 from control by t-test. Representative (d) H&E histological staining and (e) TUNEL immunofluorescence staining of excised tumor slices for PBS, Hf-DBA, H2DBB-Ru, and Hf-DBB-Ru (i.t. injection) treatment groups (left to right), respectively. d H&E, scale bar = 100 μm. e TUNEL, scale bar = 50 μm. The error bars represent s.d. values. The in vivo confocal images were obtained without repetition
