Fig. 3
From: Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Time course of DMF inhibition. In vitro determination of apparent IC50 values of DMF on RSK2CTKD activity following incubation with DMF at different time points (1 h: black, 24 h: dark grey, and 48 h light grey) prior to ERK2 activation (n = 3, all data points indicated by circles)