Fig. 5
From: Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Model of DMF inhibition. Schematic figure of the activation loop transition between inactive and activated state of the C-terminal kinase domain (consisting of the ATP binding domain and the helix bundle domain). DMF targets an allosteric site and blocks kinase activation, and vice versa
