Fig. 8
From: Defective transcription elongation in a subset of cancers confers immunotherapy resistance
A model of TEdeff-induced immunotherapy resistance. Intact transcriptional fidelity is essential for the baseline and cytokine (e.g. IFN)-inducible expression of the inflammatory response pathways that prime the tumor cell for cytolytic cell attack (left). However, in TEdeff cells, transcription elongation defects lead to the expression of spurious transcripts and poor nuclear export of the inflammatory response pathway genes. This, in turn, severely reduces the sensitivity of the tumor cell to the cytolytic T and NK cell-mediated anti-tumor mechanisms (right)
