Fig. 4

Depletion of RBX1 inhibits the growth of 17p^loss CRPC tumors in vivo. a–c Tumor growth curves (a), gross tumor images and weights (b) of xenograft tumors derived from subcutaneously implanted parental and isogenic 17p^loss DU145 cells expressing Dox-inducible RBX1 shRNA (n = 3). c RBX1 expression, cell proliferation and apoptosis in the above xenograft tumors were quantified. Scale bar, 10 mm. d–f Tumor growth curves (d), representative bioluminescent images (e), and gross tumor weights (f) of xenograft tumors derived from orthotopically implanted 22Rv1 and PC3 cells expressing Dox-inducible RBX1 shRNA (n = 5). Data are analyze by unpaired two-tailed t-test and are presented as the mean ± SD. ns not significant; **, p < 0.01