Fig. 6
From: Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
A model explaining the molecular mechanism for confining and localizing PIP3 enrichment. a Clear spatial separation between DdPTEN and PIP3 established via mutual inhibition in the presence of negative regulation and phosphatase activity. b Enlargement of the PIP3-enriched domain by the replacement of DdPTEN with HsPTEN, which lacks sufficient membrane localization. c Chemotactic signaling excludes DdPTEN from the higher concentration side by suppressing the binding site for the stably binding state
