Table 1 Marginal and conditional estimates for genetic markers at 8q24 independently associated with prostate cancer risk
From: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Variant IDa | Positionb | Allelec | RAFd | LD clustere | Conditional associationf | Marginal association | ||
|---|---|---|---|---|---|---|---|---|
OR (95%CI)g | p-value | OR (95%CI)h | p-value | |||||
rs1914295 | 127910317 | T/C | 0.68 | block 1 | 1.10 (1.08–1.12) | 7.30 × 10−25 | 1.09 (1.07–1.11) | 3.07 × 10−21 |
rs1487240 | 128021752 | A/G | 0.74 | block 1 | 1.20 (1.17–1.22) | 2.77 × 10−66 | 1.16 (1.14–1.18) | 2.97 × 10−54 |
rs77541621 | 128077146 | A/G | 0.02 | block 2 | 1.85 (1.76–1.94) | 2.93 × 10−137 | 1.83 (1.74–1.92) | 4.33 × 10−137 |
rs190257175 | 128103466 | T/C | 0.99 | block 2 | 1.60 (1.42–1.80) | 4.28 × 10−15 | 1.36 (1.22–1.53) | 6.90 × 10−8 |
rs72725879 | 128103969 | T/C | 0.18 | block 2 | 1.31 (1.28–1.35) | 1.26 × 10−83 | 1.17 (1.14–1.19) | 3.96 × 10−48 |
rs5013678 | 128103979 | T/C | 0.78 | block 2 | 1.10 (1.08–1.13) | 1.58 × 10−19 | 1.20 (1.17–1.22) | 4.44 × 10−68 |
rs183373024 | 128104117 | G/A | 0.01 | block 2 | 2.67 (2.43–2.93) | 4.89 × 10−95 | 3.20 (2.92–3.50) | 6.60 × 10−138 |
rs78511380 | 128114146 | T/A | 0.92 | block 2 | 1.19 (1.14–1.23) | 3.48 × 10−18 | 0.97 (0.94–1.00) | 0.027 |
rs17464492 | 128342866 | A/G | 0.72 | block 3 | 1.16 (1.14–1.18) | 3.01 × 10−52 | 1.17 (1.15–1.19) | 9.05 × 10−61 |
rs6983267 | 128413305 | G/T | 0.51 | block 4 | 1.18 (1.16–1.20) | 5.68 × 10−84 | 1.23 (1.21–1.25) | 3.15 × 10−135 |
rs7812894 | 128520479 | A/T | 0.11 | block 5 | 1.37 (1.33–1.40) | 1.55 × 10−122 | 1.45 (1.41–1.49) | 1.20 × 10−181 |
rs12549761 | 128540776 | C/G | 0.87 | block 5 | 1.21 (1.18–1.24) | 1.61 × 10−45 | 1.28 (1.25–1.31) | 1.38 × 10−78 |
