Table 2 Relative risk of PCa for polygenic risk score (PRS) groups

From: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Risk category percentilea

No. of individuals

Risk estimates for PRS groups

Controls

Cases

OR (95% CI)b

p-value

≤1%

530

339

0.52 (0.45–0.59)

2.11 × 10−20

1%–10%

4771

3636

0.62 (0.59–0.65)

6.26 × 10−90

10%–25%

7936

7359

0.75 (0.72–0.78)

3.62 × 10−54

25%–75%

26,464

32,743

1.00 (Ref)

 

75%–90%

7940

13,431

1.37 (1.32–1.41)

6.55 × 10−77

90%–99%

4766

11,451

1.93 (1.86–2.01)

4.13 × 10−249

>99%

528

2576

3.99 (3.62–4.40)

5.64 × 10−172

  1. Note: PRS were calculated for variants from the final stepwise model with allele dosage from OncoArray and iCOGS weighted by the per-allele conditionally adjusted odds ratios from the meta-analysis
  2. aRisk category groups were based on the percentile distribution of risk alleles in overall controls
  3. bEstimated effect of each PRS group relative to the interquartile range (25–75%) in OncoArray and iCOGS datasets separately, and then meta-analyzed across the two studies; odds ratios were adjusted for country and 7(OncoArray)/8(iCOGS) principal components
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