Table 3 Proportion of familial relative risk (FRR) and heritability (hg2) of PCa explained by known risk variants

From: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Source

No. of variants

Proportion of FRR (95%CI)

% of total FRR

hg2 (SE)

% of total hg2

8q24a

12

9.42 (8.22–10.88)

25.4

0.027 (0.011)

22.2

HOXB13b

1

1.91 (1.20–2.85)

5.2

0.004 (0.005)

3.0

All other variantsb,c

162

25.77 (22.94–29.36)

69.5

0.092 (0.010)

74.9

Total

175

37.08 (32.89–42.49)

100

0.118 (0.012)

100

  1. aConditional estimates were derived by fitting a single model with all variants from OncoArray data
  2. bRisk estimates and allele frequencies for regions with a single variant are from a meta-analysis of OncoArray, iCOGS and 6 additional GWAS3
  3. cRisk variants included from fine-mapping of PCa susceptibility loci in European ancestry populations11
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