Fig. 4 | Nature Communications

Fig. 4

From: Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli

Fig. 4

Mediation analysis. a Two-path mediation model with a representing the relation of X to M, b the relation of M to Y controlled for X, and c′ the relation of X to Y controlled for M. Mediation effects are calculated by multiplying coefficients of path a and path b and tested for significance using a bootstrap approach. b Three-path mediation model linking stimulus intensity (X) and the perceptual, motor, or autonomic dimension of pain (Y) via two sequential mediators (M1 and M2)

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