Fig. 6
Somatic mutations in PDXs/cell line and their corresponding NPC tumors. a Mutation profiles of Xeno23, 32, 47 and NPC43 and their corresponding patient tumors. Somatic mutations, including stopgain (red box), splicing (orange box), frameshift INDEL (yellow box), missense (green box) and non-frameshift INDEL (blue box), were identified by WES analysis and plotted. For each mutation plot, the left column represents mutations in patient tumor, while the right column represents those identified in each newly established PDX or cell line. The mutated gene names are labeled at the left side of each mutation plot. The shared mutations between PDX/cell line and its corresponding patient tumor are labeled in red, while the uniquely mutated gene names in either PDX/cell line or its corresponding patient tumor are labeled in black. b Bar chart illustrating the percentage of gene mutations identified in each NPC case. Gray bars indicate the shared somatic gene mutations between PDX/cell line and its corresponding patient tumor; dark gray bars reveal the unique gene mutation(s) identified in NPC patient tumor; black bars indicate the unique gene mutations found only in the newly established PDX/cell line. The numbers with brackets labeled in each bar represent the number of mutations identified for each case. The overlap of mutations between NPC PDXs/cell line and their corresponding patient NPC tumors was 82% in Xeno23, 81% in Xeno32, 64% in Xeno47, and 94% in NPC43 cell line
