Fig. 7 | Nature Communications

Fig. 7

From: Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

Fig. 7

Genetic landscape of newly established NPC tumor lines. a Circos plot showing genomic aberrations in NPC43 by WGS. Illustrations in order from inner to outer rings: (1) structural variants (orange, inter-chromosomal rearrangement; blue, intra-chromosomal rearrangement), (2) copy number alterations (green, copy number loss; red, copy number gain; range: −2 to +4), (3) non-synonymous single-nucleotide variants or small indels (purple, missense; black, splicing; orange, nonsense; red, frameshift; green, inframe indel; brown, others) with allele frequency indicated by the size of each dot (0, 20, 40, 60, 80, 100% or more), (4) density of SNVs/small indels (0, 20, 40, 60, 80, 100, 120, 140, 160 per Mbps or more), (5) chromosome scale at 1 Mbps (shades of gray, cytobands; red, centromere). High-resolution plot is illustrated in Supplementary Fig. 14. b Whole-genome profiles of chromosome copy number alterations in NPC PDXs/cell line. Overall normalized coverage across genome is shown on vertical axis

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