Fig. 1 | Nature Communications

Fig. 1

From: Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA

Fig. 1

A Manhattan plot of the combined BPH/LUTS GWAS results. The Manhattan plot shows variants with two-sided P-value < 0.10 (obtained using a logistic regression model) and high imputation information score (info > 0.90) from the BPH/LUTS meta-analysis of GWAS data from 20,621 patients and 280,541 controls of European ancestry, coming from Iceland and the UK. Shown are negative log10-transformed two-sided P-values from the unconditional analysis (y-axis) over 22 autosomes (x-axis). Dots colored in red denote variants that surpass our genome-wide significance thresholds (ranging between 1.9 × 10−7 and 5.9 × 10−10), defined using a weighted Bonferroni procedure based on functional impact of classes of variants

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