Fig. 2
From: Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
Crystal structure of ENPP1 in complex with the dinucleotide. a Domain organization of mouse ENPP1. b Overall structure of ENPP1 in complex with pApG. The N-linked sugars are shown as yellow sticks. c, d mFO – DFC omit electron density maps for pApG (c) and 3′3′-cGAMP (d) (contoured at 2.5σ) (stereo view). e Binding of pApG to the ENPP1 active site. f Recognition of pApG (stereo view). The zinc ions are shown as gray spheres. Hydrogen bonds are shown as dashed lines
