Fig. 6
From: Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes
A working model of DYNAMO1 functions during the division of mitochondrion and peroxisomes. Initially, DYNAMO1 is recruited to the division site of the mitochondrion, together with Dnm1 (Phase 1, prophase). DYNAMO1 is involved in Dnm1 assembly around the division site. Next, DYNAMO1 converts ATP to GTP on the ring of the MD machinery. A cytosolic ATP source is used for this reaction. Upon GTP generation, the MD machinery is constricted and GTPase Dnm1 pinches off mitochondrion. Moreover, the DYNAMO1-Dnm1 structure effectively generates a strong motive force for the constriction (Phase 2). MD machinery containing DYNAMO1 and Dnm1 is immediately disassembled (Phase 3). After mitochondrial division, DYNAMO1 functions in the POD machinery during meta-anaphase, in an analogous manner to that in mitochondrial division
