Fig. 1

Neuronal SIRT1 regulates macronutrient-based diet selection. a Hypothalamic Sirt1 mRNA expression of NS-OE (red) and NS-KO (blue) mice compared to wild-type mice (WT) (n = 6 per group). b–d Food intake (kcal/d) for NS-OE and NS-KO mice fed NC only (b), HSD only (c) and HFD only (d) (n = 6 per group). e, f Cumulative caloric intake for two-choice diets in 5-day diet selection experiments: NC vs. HSD (e) and NC vs. HFD (f) (n = 6 per group). Data are shown as box and whisker plots (centre line, median; box limits, upper and lower quartiles; whiskers, the minimum and maximum value of a data set). *p < 0.05. See also Supplementary Fig. 1