Fig. 4

SIRT1 in Oxt neurons specifically regulates preferences for simple sugars. Two-bottle choice tests in OS-OE (red) and OS-KO (blue) mice. a–d Results of 3-day two-bottle choice tests (100 mM glucose (a), 100 mM fructose (b), 100 mM sucrose (c) and 2% dextrin (d)) (n = 7 in the WT group; n = 6 in the OS-OE and OS-KO groups). e Results of 10-min brief access two-bottle choice tests for 100 mM sucrose over water (n = 6 per group). f, g Results of two-bottle choice tests with artificial sweeteners (0.2% saccharin (f) and 0.2% aspartame (g)) over water, given for 3 days in sugar-naive mice (n = 8 per group). h Results of 3-day two-bottle choice tests with 1.5 mM quinine (bitter taste) (n = 7 in the WT group; n = 6 in the OS-OE and OS-KO groups). Data are shown as box and whisker plots (centre line, median; box limits, upper and lower quartiles; whiskers, the minimum and maximum value of a data set). *p < 0.05. See also Supplementary Fig. 9