Fig. 1
From: Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
Hybrid polyketide synthases engineered to produce short-chain ketones. Short-chain ketone-producing polyketide synthases (PKSs) were created by engineering of LipPks1, a type I modular PKS. Catalytic domains of LipPks1 are shown in green. The non-catalytic domains are shown in gray. Linkers are shown as black line. The TE domain (blue) is derived from the erythromycin PKS. The AT domain shown in magenta is derived from the borrelidin PKS module 1, which is specific for malonyl-CoA. Enzymatic products that can be produced by each PKS were shown in the same box. AT acyltransferase, ACP acyl carrier protein, CoA coenzyme A, KAL KS to AT linker, KR ketoreductase, KS ketosynthetas, PAL Post AT linker, TE thioesterase
