Fig. 4
From: Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
Neutrophil depletion inhibits K-ras mutant lung tumors in male LR/Stat3Δ/Δ mice. a Lung surface tumor number in 14-week-old male LR/Stat3Δ/Δ mice treated with control (IgG2) (n = 4) or anti-Ly6G (n = 4) antibody. b Total inflammatory cell and lineage-specific leukocyte numbers from BALF of control (n = 4) or anti-Ly6G antibody treated (n = 4) male LR/Stat3Δ/Δ mice. c Relative expression of Arg1, Ido, Cxcl1, Ccl2, Il6, Tgfb, Il17, Tnfa, Ifng and Gzmb mRNA in whole lungs, normalized by CD45 expression, of LR/Stat3Δ/Δ male mice treated with control (n = 4) or anti-Ly6G (n = 4) antibody (data represent means ± SEM; ***P < 0.001; **P < 0.005; *P < 0.05 using two-tailed t-test, experimental replicate # 2-3). WBC, white blood cells
