Fig. 5
From: Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
IL-6 blockade reduces K-ras-induced lung tumorigenesis in male LR/Stat3Δ/Δ mice. a Lung surface tumor number in 14-week-old male LR/Stat3Δ/Δ mice after treatment with control (IgG1) (n = 5) or anti-IL-6 (n = 3) antibody. b Total inflammatory cell and lineage-specific leukocyte numbers from BALF of control (n = 5) or anti-IL-6-treated (n = 3) male LR/Stat3Δ/Δ mice. c Relative expression of Arg1, Ido, Cxcl1, Ccl2, Il6, Tgfb, Il17, Tnfa, Ifng, Foxp3, Tbx21, and Gzmb mRNA in whole lungs, normalized by CD45 expression, of male LR/Stat3Δ/Δ mice after treatment with control (n = 5) or anti-IL-6 (n = 3) antibody (data represent means ± SEM; **P < 0.005, *P < 0.05 using two-tailed t-test, experimental replicate # 2–3)
