Fig. 6
From: Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
Estrogen receptor blockade promotes lung tumorigenesis in female LR/Stat3Δ/Δ mice. a Lung surface tumor number in 14-week-old female LR/Stat3Δ/Δ mice after corn oil (n = 8) or tamoxifen (n = 3) treatment. b Total inflammatory cell and lineage-specific leukocyte numbers from BALF of female LR/Stat3Δ/Δ mice after corn oil (n = 4) or tamoxifen (n = 3) treatment. c Relative expression of Arg1, Ido, Ccl2, Il6, Tgfb, Il17, Tnfa, Ifng, Tbx21, Foxp3, and Gzmb mRNA in whole lungs, normalized by CD45 expression, of female LR/Stat3Δ/Δ mice after corn oil (n = 4) or tamoxifen (n = 3) treatment (data represent means ± SEM; **P < 0.005, *P < 0.05 using two-tailed t-test, experimental replicate # 2-3)
