Fig. 7
From: Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
Mechanisms underlying sex-associated function of epithelial STAT3 signaling in K-ras mutant lung cancer. Our findings suggest that there is a differential regulation of NF-κB activation in K-ras mutant STAT3-deficient lung epithelium within sex, and estrogen signaling plays a protective role in females by reducing the activation of NF-κB pathway and subsequent induction of an anti-tumor immune response. It also suggests that activation of NF-κB pathway in the lung of male mice drives the tumor-promoting effect of STAT3 deficiency probably by induction of IL-6 and CXCL1, and subsequent recruitment of neutrophils and induction of a pro-tumor immunosuppressive response
