Fig. 6
Olfactory deprivation via unilateral naris occlusion (UNO) alters the expression frequency of SF-biased and SM-biased ORs. a Schematic of a coronal MOE section following occlusion of the right nostril. The red box corresponds to the approximate region of the images shown in b, d, and f. b Confirmation of UNO efficiency via RNA-FISH analysis of the expression of Kirrel25,8, an activity-dependent gene that is more strongly expressed on the open (left) side of the MOE. c, e Quantitation of Olfr912-expressing (c) and Olfr1419-expressing (e) OSNs on the open and closed sides of the MOEs of mice subjected to UNO. Each line represents a different MOE section. Error bars: s.e.m. *p < 0.05, ***p < 0.001 (two-tailed paired t test); n = 12 male and 16 female sections (taken from 4 mice of each sex). d, f Representative images of Olfr912 (d) and Olfr1419 (f) expression in the MOEs of mice subjected to occlusion of the right nostril. Scale bars: 200 µm
