Fig. 5 | Nature Communications

Fig. 5

From: BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes

Fig. 5

Genomic regions differentially methylated in CSS1. The figure shows the entire three DMRs found to be differentially methylated in CSS1 cases compared to the controls. The box plots represent the distribution of median methylation values across all of the probes mapping to each region as stratified by the subtypes, i.e., Controls, CSS1, CSS4, CSS3, and NCBRS. These regions are detected in the comparison between CSS1 and controls; however, all of them show a similar pattern of methylation in all other CSS/NCBRS subtypes. Center line: median of regional methylation levels across samples; lower and upper bounds: first and third quartiles; whiskers: interquartile ranges

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