Fig. 2
From: Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
Molecular design and antigenic characterization of loop-swapped HPV33/58 chimeric VLPs. a Schematic representation of the wild types (WTs) and the chimeric HPV33/58 L1 proteins. The location of surface loops for each WT or mutated L1 protein are labeled by amino acid position. b Heatmap representations of the EC50 values of chimeric HPV33/58 VLPs based on ELISA assays against a type-specific mAb panel of HPV33 and HPV58 VLPs. The key indicates the heatmap gradient. A detailed characterization of each mAb is shown in Supplementary Table 3
