Table 2 Half-effective dosage (ED50) of double-type and triple-type chimeras in mice

From: Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Antigen category

HPV VLP

ED50 (μg)

anti-HPV33

anti-HPV58

anti-HPV52

Wild-type control

HPV33

0.066a

 > 0.3

—

 

HPV58

 > 0.3

0.006

—

Double-type chimera

H33-58HI

0.053

0.049

—

 

H58-33BC

0.043

0.019

—

Wild-type control

HPV33

0.013b

>0.3

>0.3

 

HPV58

> 0.3

0.021

>0.3

 

HPV52

 >0.3

>0.3

0.046

 

H33&58&52

0.009

0.009

0.017

Triple-type chimera

H33-58HI-52DE

0.083

0.069

0.557

 

H33-58HI-52FG

0.046

0.243

0.087

 

H58-33BC-52DE

0.009

0.014

0.341

 

H58-33BC-52HI

0.065

0.058

0.041

  1. aRefer to the detailed ED50 calculation in Supplementary Table 4
  2. bRefer to the detailed ED50 calculation in Supplementary Table 5
Back to article page