Fig. 9 | Nature Communications

Fig. 9

From: Proteolysis of histidine kinase VgrS inhibits its autophosphorylation and promotes osmostress resistance in Xanthomonas campestris

Fig. 9

A model for VgrS proteolysis-triggered bacterial stress responses. When bacteria grow under osmostress, Prc is activated and then cleaves the N-terminal peptide (NRNIDFFA) of the sensor region of VgrS to inhibit the latter’s autophosphorylation. Dephosphorylation of the VgrS–VgrR two-component signal transduction system regulates VgrR–promoter interactions and triggers the transcription of stress-response genes, which is required for X. campestris pv. campestris to resist osmostress. prc itself is controlled by VgrR, resulting in a positive feedback loop within the regulatory cascade

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