Fig. 5
From: Serotonin signals through a gut-liver axis to regulate hepatic steatosis
HTR2A mediates the inflammatory and fibrogenic action of GDS in the liver. a–d The 12-week-old WT and Htr2a LKO mice were fed HFD for 8 weeks. a–c GO gene sets were analyzed by GSEA for HFD-fed Htr2a LKO mice livers compared with WT littermates livers. Gene sets related to hepatic steatosis (a), inflammation (b), and fibrosis (c); n = 3 per group. d Relative mRNA expression of genes involved in inflammation and fibrosis as assessed by qRT-PCR in liver; n = 5 per group. Data are expressed as the means ± SEM. *P < 0.5, **P < 0.01, ***P < 0.001, one-way ANOVA with post hoc Tukey’s test (d)
