Fig. 6

HSV-P10 enhances overall survival of mice bearing breast cancer brain metastases. a Schematic representation of animal studies. b Survival curve of DB7 brain tumor-bearing FVB/N mice treated intratumorally with saline control (blue line: n = 41), HSVQ (red line: n = 38), or HSV-P10 (green line: n = 38) 7 days post tumor cell implantation. Significance in survival was assessed by Logrank (Mantel–Cox) test comparing only two survival curves per test (**p < 0.01, ****p < 0.0001). c Brain magnetic resonance imaging (MRI) of one representative long-term survivor mouse treated with HSV-P10 from Fig. 5b > 90 days post tumor cell implantation. White arrows indicate the needle track of the initial injection site. d Survival curve of HSV-P10 treated long-term survivor mice (green line: n = 5) from Fig. 5b contralaterally inoculated with 100,000 DB7 tumor cells vs. naive age-matched control mice (blue line: n = 8). Significance in survival was assessed by Logrank (Mantel–Cox) test (***p < 0.001). e Brain MRI of one representative long-term survivor mouse from Fig. 5d 45 days post tumor rechallenge. White arrows indicate the needle track of the rechallenge injection site