Fig. 6
IL-4-induced M2a-subtype MΦ activation was regulated by both the Irs2 and STAT6 pathways. a Akt phosphorylation and protein levels in the BMDM of the C57BL/6 mice after IL-4 or insulin stimulation (n = 3–4). b Expression levels of the M2a-subtype MΦ marker genes in the BMDM of the C57BL/6 mice after IL-4 or insulin stimulation (n = 4). c STAT6 phosphorylation and protein levels in the BMDM of the C57BL/6 mice after IL-4 or insulin stimulation (n = 3–4). d Expression levels of the M2a-subtype MΦ marker genes in the BMDM of the C57BL/6 mice after IL-4 stimulation following siSTAT6 transfection (n = 5–6). e STAT6 phosphorylation and protein levels in the BMDM of the control and MIrs2KO mice after IL-4 or insulin stimulation (n = 3–4). f STAT6 phosphorylation and protein levels in the BMDM of the C57BL/6 mice after IL-4 stimulation following LY294002 treatment (n = 4). N.D not-detected. The data are mean ± SEM. followed by one-way ANOVA with a post hoc test. *P < 0.05; ***P < 0.001
