Fig. 2

Acne association signal at the 15q26.1 locus (SEMA4B). a ChIP-Seq read signal intensities of TP63 binding on two samples from human neonatal foreskin keratinocytes. b Sequence logo of the TP63-binding motif highlighting the risk and protective alleles for rs34560261. The invariant cytosine (position 14) is substituted by a thymine. c Regional acne association plot, variants are coloured according to the degree of LD (r²) with the lead SNP (rs34560261). d SEMA4B not sun exposed skin eQTL from GTEx. e SEMA4B sun exposed skin eQTL from GTEx. f SEMA4B skin eQTL from MuTHER study; * rs1399238 in LD with rs34560261 (r² = 0.66) (rs34560261 was not present in the MuTHER dataset)