Fig. 8
From: ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β. A schematic representation of the key findings in this study. After injury, either by cell culture or acute pancreatitis induction, loss of Robo2 in pancreatic epithelial cells leads to non-autonomous activation of pancreatic myofibroblasts and increased T-cell infiltration, dependent on activation of the TGF-β signalling pathway
