Fig. 6 | Nature Communications

Fig. 6

From: Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

Fig. 6

Regulation of neutrophil accumulation and injury in anti-GBM induced nephritis by CD18 integrins. Wild-type mice (Itgb2+/+) and mice lacking all CD18 integrins (Itgb2−/−), lacking all FcγRs (Fcer1g−/−), deficient in CD18 only in neutrophils due to neutrophil selective CD18 silencing (miR-Itgb2 + ) or CD18 expression only in neutrophils of the CD18 deficient mice (ITGB2 + Itgb2−/−) were given anti-glomerular basement membrane antisera and glomerular neutrophil accumulation was evaluated at the indicated time points (n = 4, 4–10, 4–8, 4–6 mice of each genotype at 0, 60, 120, 240 min, respectively). Data is average ± SEM. Significant difference (p < 0.001) among all mouse strains was evaluated by ANOVA. *indicates mouse strains compared to Itgb2+/+ at 0.05 significance by Bonferroni test

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