Fig. 1
From: Ribosome-induced RNA conformational changes in a viral 3′-UTR sense and regulate translation levels
Location, structure, and function of the TYMV 3′-UTR. a TYMV gRNA and sgRNA. ORFs and the 3′-UTR are labeled. MP movement protein, PP polyprotein, CP coat protein. Red: stop codons. The CP ORF is translationally silent in the gRNA. Both RNAs end with identical 3′ ends that contain the UPD + TLS domain and both are valylated (dashed box). b Secondary structure of the 3′-UTR. Red: CP ORF stop codon. Specific parts of the structure are labeled. c Schematic of TYMV TLS tRNA mimicry and translation enhancement. The 3′ end of the viral genome is aminoacylated by the host’s valine tRNA synthetase (green). This is followed by binding of eukaryotic elongation factor 1A (eEF1A, yellow) and translation enhancement by an unknown mechanism
