Fig. 6 | Nature Communications

Fig. 6

From: Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation

Fig. 6

The proposed model of antifungal applications of TPP+-conjugates. Cdr substrates with potential antifungal activities are chemically conjugated with TPP+. The TPP+-conjugates regain the ability to kill C. albicans wild-type or resistant strains and even can eradicate highly drug-resistant biofilms. The TPP+-conjugates bypass active expulsion by efflux pumps and accumulate in the mitochondria to exert fungicidal activity by inducing mitochondrial dysfunction

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